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Division of Comparative Medicine
“…contributing to a greater reverence for life.”

• Animal Welfare Act
  
  
• Title 9 Code of Federal Regulations Subchapter A, Parts 1-3
  
  
• Good Laboratory Practice for Nonclinical Laboratory Studies Title 21 Code of Federal Regulations Part 58

• Guide for the Care and Use of Laboratory Animals
  
  
• Laboratory Animal Care Policies and Regulations
  
  
• Laws,
  
  
• Public Health Service Policy on Humane Care and Use of Laboratory Animals
  
  
• University of South Florida Policy No. 0-308, "Use of Animals in Research, Teaching, or Testing"  
  
  
• University of South Florida IACUC Principles and Procedures   Revised 05/09
  
  
  

  
  
  

GUIDELINES & REFERENCES

• 3D MRI Digital Atlas Database of Adult C57BL/6J Mouse Brain   
  
  
• Amphibians - Compendium of Drugs and Compounds Used   
  
  
• Blood Volumes and Phlebotomy    REVISED  
  
  
• Clinical Pathology Reference Ranges  
  
  
• Comparative Mammalian Brain Collections
  
  
• Design of Animal Exercise Protocols    
  
  
• Duke University - ABC's of Daily Observations     **NEW**
  
  
• Enrichment for Nonhuman Primates   
  
  
• Estrus Detection, Weaning and Sexing Mice    
  
  
• FDA Oncology Reference Tools    
  
  
• Guidelines of the American Society of Mammalogists for the Use of Wild Mammals in Research    
  
  
• Guidelines on Anesthesia and Analgesia in Laboratory Animals    
  
  
• Guidelines for the Care and Use of Mammals in Neuroscience and Behavior Research  
  
  
• Guidelines for the Use of Fishes in Research        
  
  
• Guidelines for Use of Live Amphibians and Reptiles in Field and Laboratory Research
  
  
• Guidelines to the Use of Wild Birds in Research   
  
  
• IACUC
  
  
• The IACUC Handbook - 2nd Edition
  
  
• Institutional Animal Care & Use Committee Guidebook
  
  
• Laboratory Birds: Refinements in Husbandry and Procedures (United Kingdom)
  
  
• Library Holdings of Comparative Medicine
  
  
• Merck Veterinary Manual - Eighth Edition 
  
  
• Mouse Blood Collection using the Saphenous Vein 
  
  
• Mouse Blood Collection using the Submandibular Vein    (QuickTime Player required)
  
  
• Mouse Blood Collection using the Submandibular Vein - Basic Stills     
  
  
• Mouse Cytokines
  
  
• Mouse Intubation Tutorial     Note - This will take approximately 2 minutes to load.
  
  
• Mouse Models of Immunodeficiency    
  
  
• Mouse Necropsy/Prosection   NEW  
  
  
• Mouse Prostate Collection   NEW  
  
  
• Mouse Tail Snip, Ear Punch, and Identification Procedures   
  
  
• National Cancer Institute's "Endpoints in Animal Study Proposals"
  
  
• NIAID Tutorial "How to Write an Application Involving Research Animals"
  
  
• NIOSH - "Preventing Occupational Exposures to Antineoplastic & Other Hazardous Drugs..."    
  
  
• Office of Laboratory Animal Welfare (OLAW) Commentary on Lab Animal Protocol Review Columns  
  
  
• Office of Laboratory Animal Welfare (OLAW)/PHS Policy on Humane Care and Use of Laboratory Animals - "Frequently Asked Questions"   
  
  
• "ORI Introduction to Responsible Conduct of Research"     
  
  The U.S. Department of Health and Human Services' Office of Research Integrity (ORI) promotes integrity in biomedical and behavioral research supported by the U. S. Public Health Service (PHS) at about 4,000 institutions worldwide. ORI monitors institutional investigations of research misconduct and facilitates the responsible conduct of research (RCR) through educational, preventive, and regulatory activities.
  
  "ORI Introduction to Responsible Conduct of Research" introduces the reader to the nine RCR core instructional areas in four sections that follows research from inception to planning, conducting, reporting, and reviewing research. The publication features case studies, text-box inserts, discussion questions, and electronic and printed resources.

  The web version, the pdf version, and the pdf version of the extracted animal portion of this publication are available.
  

• Rabbit Terminal Blood Collection
  
  
• Rat Intubation Tutorial   Note - This will take approximately 2 minutes to load.  
  
  
• Rodent Dosing    
  
  
• Rodent Surgery SOP 
  
  
• Rodent Surgical Techniques  
  
  
• Routes of Administration, Volumes, and Needle Gauges for Drug Administration 
  
  
• "Top Ten" Protocol Review Comments   
  
  
• "What Investigators Need to Know About the Use of Animals"   
  OLAW created this brochure to communicate to investigators their responsibilities under PHS Grants Policy and PHS Policy on Humane Care and Use of Laboratory Animals.
  
  
  

HUMANE METHODS OF EXPERIMENTATION  

• Animal Well-being   
  
  
• Design and Statistical Methods in Studies Using Animal Models of Development    
  
  
• Experimental Design in Biomedical Research  
  
  
• Humane Endpoints for Animals Used in Biomedical Research & Testing   
  
  
• National Cancer Institute's "Endpoints in Animal Study Proposals"   
  
  
• Pain and Distress in Fish     **NEW**  
  
  

ALTERNATIVES

• Altweb  
  
  
• Animal Welfare Information Center (AWIC)    
  
  
• Bibliography on Alternatives to Animal Testing
  
  
• EPA Test Guidelines/Acute Toxicity - Acute Oral Toxicity Up-And-Down-Procedure
  
  
• Interagency Coordinating Committee on the Validation of Alternative Methods
  
  
• Johns Hopkins Center for Alternatives to Animal Testing (CAAT)
  
  
• Norwegian Reference Centre for Laboratory Animal Science & Alternatives   
  
  
• TISSUE-USE-ONLY     University of South Florida Web Page

EUTHANASIA

• AVMA Guidelines on Euthanasia - June 2007     
  
  
• Public Health Service Clarification on the Use of Carbon Dioxide for Euthanasia

Please address questions to CompMed@research.usf.edu, telephone (813) 974-9796, fax (813) 974-9432; IACUC@research.usf.edu, telephone (813) 974-7106, fax (813) 974-7091.

12901 Bruce B. Downs Blvd., MDC 20, Tampa, FL 33612-4742

Phone: (813) 974-9796 - Fax: (813) 974-9432

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